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Have Eli Lilly’s weight-loss drug gains hit a plateau?

Sales of Lilly’s weight-loss drugs Mounjaro and Zepbound are eking higher and underwhelming analysts.

J. Edward Moreno

Revenues from popular weight-loss drugs made by Eli Lilly are flattening out. That’s disappointing to investors who were hoping for bigger gains. 

The company’s GLP-1 medications, Zepbound and Mounjaro, have made billions since they entered the market in 2023 and 2022, respectively. But theyre not delivering the same double-digit growth they once did. 

Investors sent the stock down more than 12% in early trading. 


Eli Lilly made $1.25 billion in sales from Zepbound, up from $1.2 billion in the previous quarter and sharply below the $1.76 billion that analysts had expected. It made $3.1 billion from Mounjaro, basically flat from the previous quarter and also falling short of analysts’ estimates. 

Mounjaro and Zepbound are Eli Lilly’s smaller, but still mighty, competitors to Novo Nordisk’s Ozempic and Wegovy, which got in on the weight-loss drug craze early.

But even Novo Nordisk has been experiencing normalization in sales: Ozempic, the most popular GLP-1 drug, had its best quarter in December when it made the company more than $30 billion, and it hasn’t beat that level since. 

The drugs make so much money in part because theyre not cheap. A month’s supply of Zepbound will run you about $1,000. Employers and patients have had to eat that price, and have been looking for bargain versions.

Eli Lilly and Novo Nordisk, naturally, dont like that other companies are making their drugs for cheaper.

The active ingredient in Zepbound and Mounjaro, tirzepatide, was recently taken off the FDA’s shortage list. Eli Lilly was quick to send cease-and-desist letters reminding bargain pharmacies like Hims & Hers that they aren’t able to make copycat versions anymore.

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As the war with Iran produces the biggest spike in US gas prices since Hurricane Katrina, car retailer CarMax is continuing to see heightened interest in EVs, hybrids, and plug-in hybrids.

“From Feb 1st - March 1st (inclusive), compared to March 2nd to March 15th (inclusive), we saw a 9.3% lift in page views for these vehicles,” a spokesperson for the company told Sherwood News.

As industry insiders recently told us, EV interest climbs when gas prices rise. That appears to be holding true even without EV tax credits, which the Trump administration ended under its new budget package.

CarMax also saw EV searches spike in 2022, amid Russia’s invasion of Ukraine and the resulting oil price spike.

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That total will continue to climb this year, since the Supreme Court’s February tariff ruling largely leaves the 25% levy on vehicles and auto parts untouched.

Toyota has taken the biggest hit, projecting more than $9 billion in tariff costs in its fiscal year ending this month, while Detroit’s big three automakers — Ford, GM, and Stellantis — were hit with a combined $6.5 billion tariff charge in 2025.

In the fourth quarter, automakers sold about 8% fewer imported vehicles in the US compared to the same period a year ago, per the Automotive News Research & Data Center.

Tariff charges come at a rough time for legacy carmakers, which are also scaling back EV plans following the Trump administration’s elimination of tax credits and fuel standard goals. According to Automotive News, the cost of EV write-downs and restructuring is, so far, nearly $70 billion.

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