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Lilly reports positive final trial results for weight-loss pill, says it’s headed for regulatory approval

Eli Lilly reported encouraging trial results for its next-generation weight-loss pill, putting it on track to file for regulatory approval by the end of the year.

The pill, orforglipron, resulted in up to 10.5% weight loss in overweight or obese patients with diabetes in a late-stage trial, Lilly said Tuesday. The company shot up more than 4% on Tuesday.

“With these positive data in hand, we are moving with urgency toward global regulatory submissions to potentially meet the needs of patients who are waiting,” Kenneth Custer, Lilly’s head of cardiometabolic health, said in a statement. “If approved, we are ready to offer a convenient, once-daily pill that can be scaled globally — removing barriers and redefining how obesity is treated around the world.”

The company reported similar results in a late-stage trial less than three weeks ago. That trial disappointed Wall Street, which was hoping for higher weight-loss numbers from the once-daily pill. That news overshadowed a cheery earnings report, which showed its weight loss drugs outsold Novo's for the first quarter ever.

Even with Tuesday's gains, the stock is down over 10% in the past month.

Analysts at Bank of American reiterated their "buy" rating and $900 price target on Lilly after the announcement, saying its still ahead of the game when it comes to finding the next weight loss drug. "To us, LLY undisputedly remains in pole position in obesity," they wrote on Tuesday.

While Lilly's pill may not help patients lose more weight than the injectables currently on the market, there are a still some major upsides:

  1. Pills are less scary than needles, so naturally more people will likely be pulled in.

  2. Pills are cheaper to manufacture than injector pens. This is particularly important as both Novo and Lilly struggle to get insurance providers to cover their drugs and build direct-to-consumer models.

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Oracle soars after TikTok signs agreement to sell its US operations to consortium that includes the cloud computing giant

Oracle is up 5.5% in premarket trading on Friday following yesterday’s news that TikTok owner ByteDance signed contracts with three major investors who are leading a joint venture to take over the short-form video app’s US operations, per a widely-cited company memo from TikTok CEO Shou Zi Chew.

The trio of parties in that consortium are the cloud computing company, private equity firm Silver Lake, and MGX, a tech investment company backed by Abu Dhabi.

Per reports, the structure of the deal is roughly aligned with what was outlined in September, which valued TikTok’s US operations at about $14 billion. Relative to some less-popular peers, that seems like a pretty low price tag, so picking up doomscrolling on a discount (or if you prefer, short-term video browsing on a budget) looks to be a worthy catalyst for the bump in the beaten-down hyperscaler’s shares. And that’s even before mentioning the potential for Oracle’s cloud business to enhance its preexisting relationship with TikTok.

CAMARILLO, CA FEBRUARY 09: A cannabis farm worker de-leafs cann

Trump signs executive order expediting reclassification of marijuana as a less dangerous drug

Rescheduling would lift regulatory pressures that have been weighing on US cannabis operators’ margins. Shares of weed companies, many of which don’t sell cannabis in the US, tumbled an hour before the executive order was signed.

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Rivian climbs as it rolls out a “universal hands-free” update and scores an upgrade from Baird

Shares of EV maker Rivian are on pace for their 10th best day of 2025 on Thursday, following an upgrade from Baird to “buy” from “hold” and the rollout of its new hands-free driving update.

Baird raised its price target on Rivian nearly 79% to $25, writing that “2026 is the year of R2.”

Meanwhile, Rivian says its new hands-free feature will allow drivers to take their hands off the wheel across 3.5 million miles of US and Canadian roads.

Despite referring to it as universal hands-free driving, the EV maker says the feature will not stop or slow for traffic lights or stop signs, follow navigation systems, or make turns, and will function only on roads with visible lane lines.

Rivian revealed the update at its AI Day last week, when it also hinted at a robotaxi plan.

Meanwhile, Rivian says its new hands-free feature will allow drivers to take their hands off the wheel across 3.5 million miles of US and Canadian roads.

Despite referring to it as universal hands-free driving, the EV maker says the feature will not stop or slow for traffic lights or stop signs, follow navigation systems, or make turns, and will function only on roads with visible lane lines.

Rivian revealed the update at its AI Day last week, when it also hinted at a robotaxi plan.

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The stock market loves your rising electricity bill

Utilities with a footprint in the massive PJM Interconnection, the country’s largest power grid, were up Thursday after prices set in a key auction hit a record high of $333.44 per megawatt-day.

Such power providers, including Talen Energy, Constellation Energy, and Vistra, saw tidy gains shortly before midday.

“This auction leaves no doubt that data centers’ demand for electricity continues to far outstrip new supply, and the solution will require concerted action involving PJM, its stakeholders, state and federal partners, and the data center industry itself,” Stu Bresler, set to become PJM’s chief operating officer next month, told Reuters.

As I’ve previously mused, political pushback from high power prices, partially created by the AI boom, could become a constraint on development of such sites. Democrats in the US Senate are now calling for hearings on the issue.

It’s fertile political soil. This morning’s US CPI report for November showed electricity prices up nearly 7% year over year, the highest since the tail end of the postpandemic inflation in April 2023.

“This auction leaves no doubt that data centers’ demand for electricity continues to far outstrip new supply, and the solution will require concerted action involving PJM, its stakeholders, state and federal partners, and the data center industry itself,” Stu Bresler, set to become PJM’s chief operating officer next month, told Reuters.

As I’ve previously mused, political pushback from high power prices, partially created by the AI boom, could become a constraint on development of such sites. Democrats in the US Senate are now calling for hearings on the issue.

It’s fertile political soil. This morning’s US CPI report for November showed electricity prices up nearly 7% year over year, the highest since the tail end of the postpandemic inflation in April 2023.

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