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Moderna misses in Q4, stock does what it’s done for nearly 8 months straight: goes down

Moderna’s main revenue driver, the COVID-19 vaccine, is bringing in a fraction of what it used to.

J. Edward Moreno

Moderna shares slipped in early trading after the vaccine maker missed Wall Street estimates.

Moderna reported a $2.91 loss per share, compared to the $2.68 loss per share analysts polled by FactSet were expecting. It reported about $1 billion in sales, above the $943 million analysts expected. Its profits were impacted by an unexpected $238 million charge for a canceled manufacturing contract during the quarter.

Moderna and Pfizer were given government contracts to quickly produce a COVID-19 vaccine in 2020. But Moderna’s portfolio is less diverse than Pfizer’s, and the COVID-19 vaccine remains its top revenue driver even as demand dwindles.

Moderna said last month that it expects to post between $1.5 billion and $2.5 billion of revenue in 2025, compared with the nearly $3 billion analysts expected prior to the guidance.

Moderna’s stock got a bump in January after Oracle Chairman Larry Ellison said at a White House presser that artificial intelligence has the potential to make personalized vaccines to detect and prevent cancer. Though not named, the drugmaker happens to be working on exactly that kind of technology.

Growing concern over bird flu has also given investors optimism for Moderna. Last month (prior to President Trump taking office), Moderna was awarded $590 million from the Department of Health and Human Services to help develop a vaccine to protect humans from bird flu. On Thursday, Trumps pick to run HHS, vaccine skeptic Robert F. Kennedy Jr., was confirmed to run the agency.

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Chip stocks post record outperformance of software companies in never-before-seen divergence

One session in 2026 brings one thing we’ve never seen before in markets: a massive divergence between the two big parts of the technology sector.

The VanEck Semiconductor ETF absolutely trounced the iShares Expanded Tech Software ETF today, with the former gaining 3.7% leaving while the latter dropped 2.9%.

The 6.6-percentage point gap is the biggest outperformance for SMH versus IGV on record, going back to December 2011.

Since these two are both parts of a broader technology whole, it’s rare to have one up a ton while the other gets shellacked. The rolling one-year correlation of daily returns for these two ETFs was about 0.8 heading into today.

There have been only three sessions (including today) where the chip stock ETF was up at least 1.5% while the software ETF was down 1.5% or more. We’ve never seen SMH gain 2% while IGV fell 2% before Friday’s session. And there’s been only one session where the reverse happened (November 11, 2024).

The opening trading day of 2026 was phenomenal for the AI picks and shovels trade, while very poor for their more downstream peers.

How and why did this happen? Who knows really, but this looks like the kind of thing where a couple major funds decide to keep their total AI exposure stable but lean into a hardware-over-software tilt when adjusting their positioning at the start of the year, which kicks off intraday momentum that forces everyone else along for the ride.

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AI downstream stocks tumble even as their picks and shovels peers soar

While the AI picks and shovels stocks are enjoying a strong start to 2026, the same can’t be said for the companies more downstream in this theme — even most of the hyperscalers.

The S&P 500’s biggest losers today include:

1929 Andrew Ross Sorkin Sherwood News

Why the 1929 stock market crash still matters, almost a century later

Andrew Ross Sorkin’s new book, “1929,” follows the foremost financiers of the era through the market’s darkest days and the aftermath that created Wall Street as we know it.

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