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Novo Nordisk, Eli Lilly rise after Pfizer scraps obesity pill

Pfizer will stop developing a weight-loss pill after it was linked to liver injury in one patient enrolled in a clinical trial, giving a boost to Novo Nordisk and Eli Lilly, which are fighting to keep their place at the center of the weight-loss drug market.

Pfizer’s once-daily pill, called danuglipron, won’t advance into the final stage of testing. Pfizer was flat on the news while Novo and Lilly rose in early trading.

Novo, which makes Ozempic and Wegovy, and Lilly, which makes Zepbound and Mounjaro, brought in over $40 billion in revenue from GLP-1 drugs in 2024. Meanwhile, the race to make the next blockbuster weight-loss drug is heating up.

Novo, which makes Ozempic and Wegovy, and Lilly, which makes Zepbound and Mounjaro, brought in over $40 billion in revenue from GLP-1 drugs in 2024. Meanwhile, the race to make the next blockbuster weight-loss drug is heating up.

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Vistra and Oklo soar on nuclear energy deals with Meta to support data center boom

AI utility darling Vistra and zero-revenues nuclear company Oklo are flying higher on Friday after both companies announced deals with Meta.

Shares of both companies are up double digits as of 7:30 a.m. ET.

The social media giant signed a 20-year power purchase agreement with Vistra, which will see it buy the output of three nuclear plants “to support Meta's operations in the region.” Per the press release, more than 15% of the contracted capacity from this deal will constitute a new addition to the PJM region, home to the nation’s largest power grid and ground zero for rising electricity costs. The pact is reminiscent of Meta’s deal with Constellation Energy in June, another 20-year PPA of what’s generated from a nuclear plant in Illinois.

Meta’s agreement with Oklo “provides a mechanism for Meta to prepay for power and provide funding to advance project certainty for Oklo’s Aurora powerhouse development,” with the nuke company aiming for the first phase to be active as soon as 2030, also “to support Meta’s data centers in the region.”

The Zuckerberg-led firm also struck a deal with privately held firm TerraPower to develop up to eight reactors and storage system plants in the US, the first of which is hoped to be delivered as soon as 2032.

The Trump administration has touted nuclear energy as a way to solve its competing priorities in the development of artificial intelligence. Signum Global senior US policy analyst George Pollack has argued that US leadership can only realize two of these three objectives: preside over an AI boom, boost fossil fuel production at the expense of renewables, and avoid household angst over high energy prices. However, the long lead times involved with developing and deploying nuclear power, as two of agreements show, are seemingly incompatible with short-term fixes. On the other hand, the ambitious, multi-year data center buildout plans envisaged by hyperscalers help explain why they’re willing to wait and plan ahead to lock down energy supply.

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America now has more job seekers than available jobs

US job openings fell to 7.15 million in November, down from 7.45 million in the previous month, marking the lowest level since September 2024, according to BLS’s Job Openings and Labor Turnover Summary (JOLTS) report released Wednesday. 

The figure came in below all economist forecasts in a Bloomberg survey and declined across most industries, with the biggest pullback seen in leisure & hospitality, health care & social assistance, and transportation and warehousing. Only a few industries, including construction and retail, added jobs.

Hiring slowed as well, while layoffs declined to a six-month low, extending the “hire less, fire less” mode that has defined the US labor market for much of the past year — and that shift is making life even tougher not just for aspiring job switchers, but also for those trying to land a job in the first place.

Job seekers vs. job openings
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AST SpaceMobile rises after favorable commentary from BofA

Mobile-services-from-space play — and retail investor favorite — AST SpaceMobile rose after receiving a target price upgrade from Bank of America analysts.

In a note published Thursday, BofA telecom services analysts lifted their price target for the stock to $100 from $85, while noting that the low-Earth orbit satellite industry — which supercharged stocks like Rocket Lab, Planet Labs, and AST in 2025 — is set to gain more attention this year:

“We expect the momentum to intensify in 2026 as providers like ASTS and Starlink jockey to offer full cellular service and capture subscribers. Debates will likely grow regarding Starlink’s plans to offer full cellular service and regulatory decisions on Ligado and EchoStar spectrum transactions are events to watch. Carrier partnerships could evolve and pricing and plan decisions should be clearer by year end as ASTS approaches full constellation operability.”

Still, they maintained their “neutral” rating on the stock, saying they “await progress on ASTS 1) fully producing and subsequently launching its BlueBird satellite constellation, 2) successfully operating the constellation, and 3) capturing subscribers and turning them into revenue paying subscribers before becoming more constructive on the story.”

The market has been less reticent: the money-losing company’s shares are up approximately 300% over the last year.

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