UniQure surges after encouraging trial results for Huntington’s treatment
UniQure rose more than 150% in early trading Wednesday after it released trial results that showed its experimental gene therapy for Huntington’s disease slowed its progression by 75% after three years.
The treatment, AMT-130, is a one-time treatment for Huntington’s, a genetic brain disease that degrades cognitive function and muscle control. There is currently no cure for the disease.
UniQure said it plans to submit the treatment for approval to the Food and Drug Administration in the first quarter of 2026, meaning it could become available to patients later that year. The company currently makes nearly all of its revenue from gene therapies that treat hemophilia.
I will talk about Opendoor's product frequently and its stock rarely. That's because my job is to build the product and the company, and that will have good secondary outcomes.
Tomorrow is the first day I am allowed to buy $OPEN and my family is buying $1M at the open.
Opendoor Technologies made its biggest-ever intraday comeback on Friday, from down more than 20% to closing flat, and surged on Monday as management revealed a dividend of tradable warrants (which will cause headaches for short sellers) along with the company’s Q3 results after the market closed on Thursday.
Getting insiders to buy more stock and have their incentives aligned with shareholders has been something that EMJ Capital’s Eric Jackson, the architect of the surge of retail interest in the online real estate company, has stressed. Jackson flagged his previous experience with Carvana — when CEO Ernie Garcia and many directors bought more shares of the company even as it was nose-diving — as giving him greater confidence in owning that name.
CoreWeave reported a strong sales beat in Q3, with bottom-line results to match.
Revenue: $1.36 billion (compared to analyst estimates of $1.23 billion and guidance for $1.26 billion to $1.30 billion)
Adjusted operating income: $217.15 million (estimate: $177.2 million, guidance: $160 million to $190 million)
Those figures exceeded every estimate among analysts polled by Bloomberg. And more strong sales seem to be in the pipeline: CoreWeave’s revenue backlog swelled to $55.6 billion at the end of the quarter, nearly double the $30.1 billion at the end of Q2.
If there’s a fly in the ointment, it’s that CoreWeave seems to be having a little trouble getting as much compute up and running as Wall Street had hoped for, with active power of 590 megawatts at the end of the quarter, while analysts were anticipating nearly 625 megawatts.
When I look at this chart of CoreWeave’s revenue backlog, and in particular how much is slated to be realized within the next 24 months, all I can think is, “That’s got to mean a lot of capex. And power.”
However, there’s much less drama around this quarter’s results than the last one. That’s because its lock-up period expired shortly after CoreWeave’s impressive Q2 results, catalyzing a wave of profit taking in the AI darling.
Rigetti Computing reported sales a bit shy of estimates along with a modestly smaller-than-expected loss.
For Q3, the quantum computing firm posted:
Revenue: $1.9 million (compared to an analyst consensus estimate of $2.17 million)
Adjusted earnings per share: -$0.03 (estimate: -$0.05)
The prospect of government support has been a major catalyst for the quantum space in recent months, including the US government deeming the technology an R&D priority, which was followed by a report that the Trump administration was in talks to accumulate equity stakes in Rigetti and its peers. That report, however, was quickly contradicted by separate reports.
Plug Power is little changed in after-hours trading after posting Q3 results a bit ahead of estimates.
The on-again, off-again meme stock and hydrogen fuel cell company reported:
Revenue: $177.1 million (compared to estimates for $175.05 million)
Adjusted earnings per share: -$0.12 (estimate: -$0.13)
In its Q2 results, Plug has set a goal of achieving gross margin breakeven on a run-rate basis as an exit rate for Q4 2025 (that is, ending the quarter in a position where revenues at least equal the cost of goods sold). This goal was not reiterated in the press release for Q3.
Plug popped double digits in premarket trading earlier today after announcing that it “has signed a non-binding Letter of Intent to monetize its electricity rights in New York and one other location and collaborate with a US data center developer.” However, that news was apparently overshadowed by another tidbit in the release: that Plug would be abandoning its pursuit of a $1.7 billion loan guarantee from the US Department of Energy (and along with it, projects that would have boosted its hydrogen production).
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