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Theranos: The rise and fall of a company that promised to change the world

Theranos: The rise and fall of a company that promised to change the world

The "next Steve Jobs". Every business magazine cover. A genius. The world's youngest self-made female billionaire. For a few years in the early 2010s, the accolades just kept coming for Elizabeth Holmes, the founder of biotechnology company Theranos.

Holmes and her COO Ramesh Balwani were promising, in classic Silicon Valley style, to change the world. This week they both went on trial, charged with multiple counts of conspiracy and fraud.

Holmes' grand vision was in blood testing. Theranos supposedly developed, or would develop, a way to run 200+ medical tests, from just a few drops of blood. That pitch ended up raising millions in funding, each round building hype and expectation that saw Holmes meet world leaders, go on TV and amass a personal fortune of $4.5bn+ on paper, as Theranos reached a dizzying $9bn valuation in early 2014.

Would you like to see a menu?

Although the company's website has long since disappeared, thanks to a web archive we can see that there was once even a "menu" with prices for every single test that Theranos could supposedly run. Want to check your Vitamin B-12 levels? That's $10.26. Want a diabetes assessment? $18.39. The only problem of course, was that the innovative one-drop blood tests didn't work.

After some great investigative reporting by the WSJ and other news outlets, the cracks started to appear. In 2015 an article in the Journal of the American Medical Association criticized Theranos for operating in stealth and not having their results peer-reviewed. Employees started saying that the "innovative blood test" technology was barely being used, with traditional techniques doing the bulk of testing. Lawsuits started popping up from previous investors. Deals with Walgreens and Safeway got cancelled. Media scrutiny intensified and the list of lawsuits only got longer and longer.

It's hard to say exactly when Theranos became entirely worthless. Technically the company didn't close until September 2018, but as early as March 2017 Rupert Murdoch, one of the early investors, sold his shares — originally worth $125m — for just $1 in order to harvest the tax loss.

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Only days after releasing two versions of its next-gen AI model, Anthropic has disabled them for users worldwide.

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Last week, the company released to the public its much-anticipated Claude Fable 5 model (and its restricted version Claude Mythos 5, which is still being tested with trusted partners). Anthropic said in a blog post announcing the action that officials cited national security concerns with the new models, while offering few specific details.

The post said that the government gave the company “verbal evidence of a potential narrow, non-universal jailbreak” of the public Fable 5 model. A jailbreak is a means by which users can evade restrictions built into the code to unlock prohibited functionality. Anthropic downplayed the significance of the attack, and said other major models, such as OpenAI’s GPT-5.5, could also be affected by the technique described.

Fears of these first Mythos-class models being misused are running high, after Anthropic warned the cybersecurity world in May that the advanced cyber capabilities of Mythos have rapidly discovered thousands of vulnerabilities in ubiquitous software, leading to the decision to restrict the full version of the model to a close group of trusted partners for testing.

This morning, Axios reported that Anthropic technical staff have flown to Washington to meet with White House officials to resolve the issue.

The Wall Street Journal is reporting that the Trump administration’s decision to take action against Anthropic was prompted by discussions that Amazon CEO Andy Jassy had with officials, including Treasury Secretary Scott Bessent. According to the report, Amazon researchers said they had been able to evade some of Fable 5’s security restrictions using specific prompts. Amazon is a major investor in Anthropic.

Anthropic is currently suing the US government to fight the Pentagon’s blacklisting of the company on national security grounds.

Last week, the company released to the public its much-anticipated Claude Fable 5 model (and its restricted version Claude Mythos 5, which is still being tested with trusted partners). Anthropic said in a blog post announcing the action that officials cited national security concerns with the new models, while offering few specific details.

The post said that the government gave the company “verbal evidence of a potential narrow, non-universal jailbreak” of the public Fable 5 model. A jailbreak is a means by which users can evade restrictions built into the code to unlock prohibited functionality. Anthropic downplayed the significance of the attack, and said other major models, such as OpenAI’s GPT-5.5, could also be affected by the technique described.

Fears of these first Mythos-class models being misused are running high, after Anthropic warned the cybersecurity world in May that the advanced cyber capabilities of Mythos have rapidly discovered thousands of vulnerabilities in ubiquitous software, leading to the decision to restrict the full version of the model to a close group of trusted partners for testing.

This morning, Axios reported that Anthropic technical staff have flown to Washington to meet with White House officials to resolve the issue.

The Wall Street Journal is reporting that the Trump administration’s decision to take action against Anthropic was prompted by discussions that Amazon CEO Andy Jassy had with officials, including Treasury Secretary Scott Bessent. According to the report, Amazon researchers said they had been able to evade some of Fable 5’s security restrictions using specific prompts. Amazon is a major investor in Anthropic.

Anthropic is currently suing the US government to fight the Pentagon’s blacklisting of the company on national security grounds.

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