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Novo Nordisk dips after latest trial on its new weight-loss drug disappoints

Novo Nordisk shares fell after the results for the latest trial of its next-generation weight-loss shot, CagriSema, disappointed investors as the race for the next miracle weight-loss drug heats up.

CagriSema helped patients lose 15.7% of their weight over 68 weeks, compared to 3.1% with a placebo, Novo Nordisk reported. In an earlier trial, patients lost 22.7% of their body weight in the same time span.

Patients on Novo Nordisk’s blockbuster weight-loss drugs Ozempic and Wegovy lose about 15% of their body weight in 68 weeks. If the latest trial on CagriSema holds up, it would be just as effective as the drugs Novo Nordisk already sells.

The Danish pharmaceutical giant is looking to develop a successor drug, especially considering that Eli Lilly’s weight-loss drugs (which entered the market later) appear to be more more effective than Novo Nordisk’s. Amgen is also looking to enter the weight-loss drug arena with its new drug MariTide, which has shown promising results in its trials thus far.

Patients on Novo Nordisk’s blockbuster weight-loss drugs Ozempic and Wegovy lose about 15% of their body weight in 68 weeks. If the latest trial on CagriSema holds up, it would be just as effective as the drugs Novo Nordisk already sells.

The Danish pharmaceutical giant is looking to develop a successor drug, especially considering that Eli Lilly’s weight-loss drugs (which entered the market later) appear to be more more effective than Novo Nordisk’s. Amgen is also looking to enter the weight-loss drug arena with its new drug MariTide, which has shown promising results in its trials thus far.

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Pinterest sinks after weak revenue guidance and Q3 adjusted EPS misses estimates by 10%

Pinterest plunged nearly 18% in premarket trading on Wednesday, after the company reported lower-than-expected earnings and a weak holiday quarter forecast after the bell on Tuesday.

The social media platform posted adjusted earnings per share of $0.38, below Wall Streets $0.42 estimates, while revenue matched analysts expectations at $1.05 billion, up 17% from a year earlier.

The fly in the earnings ointment appears to be the guidance, however, with Pinterest expecting Q4 sales of only $1.31 billion to $1.34 billion, with the midpoint trailing analysts $1.34 billion forecast.

Global monthly active users came in at an all-time high of 600 million, beating expectations, but average revenue per user came in at $1.78, slightly shy of projections. During the earnings call, CFO Julia Donnelly said the company saw pockets of moderating ad spend in the third quarter as “larger US retailers navigate tariff-related margin pressure.

The companys soft results come as its peers, including Meta, Amazon, and Alphabet, recently reported strong digital ad sales.

CEO Bill Ready said Pinterest’s AI push is “paying off,” highlighting last weeks launch of its AI-powered shopping assistant, Pinterest Assistant. Still, growth in its core North American market — which generates roughly three-quarters of its revenue — remains a drag heading into the holiday season.

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