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Novo Nordisk sinks after its experimental obesity drug falls short of Eli Lilly’s in head-to-head trial

Novo Nordisk sank after the newest generation of its weight-loss shot, CagriSema, failed to show it was more effective than tirzepatide, the weight-loss and diabetes drug sold by Eli Lilly.

In a head-to-head trial, patients taking Novos drug lost 23% of their body weight after 84 weeks, compared to 25.5% with tirzepatide. Novo said it is exploring additional trials to test CagriSema, including higher-dose combinations.

The results are a hit to Novo, which was the first to bring GLP-1s to market but has now been outsold by Eli Lilly and faces increased competition from new competitors planning to bring weight-loss drugs to market. Earlier this month, Novo predicted that its sales would decline by between 5% and 13% in 2026 amid rising competition.

The company recently debuted its Wegovy pill, the first GLP-1 pill for weight loss to come to market. Early uptake has been strong, but Lillys pill, orforglipron, is also coming to market later this year.

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SpaceX gets a wave of bullish ratings from Wall Street analysts

SpaceX received more than a dozen positive analyst calls on Tuesday — including from major Wall Street banks — as they initiate coverage on Elon Musk’s space and AI company.

SpaceX went public on June 12 at a $2.2 trillion valuation, the largest debut in history. While the company hasn’t yet posted a profit, it seems to have convinced Wall Street that it will get there and grow its valuation on the way.

Of the at least 17 analysts that gave a rating on Tuesday, all but one gave it a “buy” or “outperform” rating. MoffettNathanson was "neutral."

The ratings come as SpaceX joined the Nasdaq 100 index, a benchmark tech-heavy basket of companies that underpins millions of portfolios. The inclusion adds built-in demand for the stock from index funds and ETFs.

Still, SpaceX fell more than 5% on Tuesday amid a broader sell-off, and is currently effectively flat from its opening price of $150 a share.

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