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FDA approves new non-opioid painkiller made by Vertex, sending its shares higher

Vertex Pharmaceuticals’ share price rose Friday morning after the Food and Drug Administration approved its novel non-opioid painkiller, Journavx.

Vertex Pharmaceuticals is the first drugmaker in decades to have a non-opioid approved to treat moderate to severe acute pain. The FDA said the approval of Journavx underscores its efforts to bring more non-opioid painkillers to the market.

Opioids, a class of drugs that includes heroin, are highly addictive because they trigger a surge of dopamine, the body’s reward system. How Journavx works, in the FDA’s words: Journavx reduces pain by targeting a pain-signaling pathway involving sodium channels in the peripheral nervous system, before pain signals reach the brain.

Opioids to treat pain, first championed by now defunct Purdue Pharma, have been widely blamed for the opioid epidemic that has led to countless deaths and addictions. Generic opioids are still produced by companies like Teva Pharmaceuticals and McKesson.

Opioids, a class of drugs that includes heroin, are highly addictive because they trigger a surge of dopamine, the body’s reward system. How Journavx works, in the FDA’s words: Journavx reduces pain by targeting a pain-signaling pathway involving sodium channels in the peripheral nervous system, before pain signals reach the brain.

Opioids to treat pain, first championed by now defunct Purdue Pharma, have been widely blamed for the opioid epidemic that has led to countless deaths and addictions. Generic opioids are still produced by companies like Teva Pharmaceuticals and McKesson.

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Ford dips as another large fire breaks out at the New York Novelis aluminum plant

Shares of US auto giant Ford are down more than 2% on Thursday morning following reports of another major fire at its primary aluminum supplier’s plant in Oswego County, New York.

Local media reported that a four-alarm fire broke out at the Novelis plant, which supplies 40% of the aluminum sheet for the US auto industry, on Thursday morning.

Last month, Ford said a September fire at the plant would hit its earnings by between $1.5 billion and $2 billion in the fourth quarter. The company said it would be able to mitigate about $1 billion of that next year.

As of 10:15 a.m. ET, local officials said the fire is under control and everyone had been safely evacuated. Novelis previously said it would be able to restart operations at the part of the plant most damaged by the September fire next month.

Last month, Ford said a September fire at the plant would hit its earnings by between $1.5 billion and $2 billion in the fourth quarter. The company said it would be able to mitigate about $1 billion of that next year.

As of 10:15 a.m. ET, local officials said the fire is under control and everyone had been safely evacuated. Novelis previously said it would be able to restart operations at the part of the plant most damaged by the September fire next month.

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