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Eli Lilly tumbles after selling way fewer weight-loss drugs than expected

Shares of Eli Lilly are tumbling after sales of its well-known GLP-1 weight-loss drugs massively undershot Wall Street’s expectations in the fourth quarter.

The company said on Monday that it made approximately $1.9 billion selling Zepbound and $3.5 billion selling Mounjaro in the final quarter of 2024. Analysts polled by FactSet estimated $2.1 billion for Zepbound and $4.4 billion for Mounjaro. 

Both are the same drug (tirzepatide), but Mounjaro is the brand name approved to treat diabetes and Zepbound can be prescribed for a wider range of conditions.

Eli Lilly has struggled to keep up with high demand for its weight-loss drugs. For a chunk of 2024, these drugs were considered in shortage by the US Food and Drug Administration, which allowed copycat compound versions to be sold by companies like Hims & Hers.

“We continued to make progress on our manufacturing build-out, and U.S. supply across all doses of tirzepatide was available throughout Q4,” Eli Lilly CEO David A. Ricks said in a statement. “The rest of our medicines performed within our expectations.”

Ozempic and Wegovy, two other popular GLP-1 weight-loss drugs made by Novo Nordisk, have also faced shortages and have flattened in recent quarters.

Both are the same drug (tirzepatide), but Mounjaro is the brand name approved to treat diabetes and Zepbound can be prescribed for a wider range of conditions.

Eli Lilly has struggled to keep up with high demand for its weight-loss drugs. For a chunk of 2024, these drugs were considered in shortage by the US Food and Drug Administration, which allowed copycat compound versions to be sold by companies like Hims & Hers.

“We continued to make progress on our manufacturing build-out, and U.S. supply across all doses of tirzepatide was available throughout Q4,” Eli Lilly CEO David A. Ricks said in a statement. “The rest of our medicines performed within our expectations.”

Ozempic and Wegovy, two other popular GLP-1 weight-loss drugs made by Novo Nordisk, have also faced shortages and have flattened in recent quarters.

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The Trump administration is reportedly planning a 50% made-in-America requirement for USMCA tariff relief

Qualifying for USMCA-related lower tariffs may soon require more US-made vehicle components, according to reporting by The Wall Street Journal.

The Trump administration is reportedly planning to introduce a 50% US content requirement for vehicles covered by the trade pact to receive lower tariffs. The content would be measured by cost, according to the WSJ.

There currently isn’t any US-specific requirement for those lower tariff rates, but in order to receive preferential tariffs, vehicles are must contain at least 75% regional content (components made in North America). Per Reuters reporting, the Trump admin is seeking to raise the regional requirement to 82%.

These reported plans are subject to change as the US negotiates USMCA terms with Mexico over the next few months.

Overall, Tesla will likely have the easiest time qualifying for any stricter requirements. The automaker’s vehicles contained the highest amount of US/Canadian content in 2025, according to American University research. Ford, GM, and Stellantis all scored lower.

Notably: the underlying government data that many domestic content measurements rely on intentionally combines US and Canadian components, so it’s difficult to know exactly how much of any given vehicle is specifically US-made.

There currently isn’t any US-specific requirement for those lower tariff rates, but in order to receive preferential tariffs, vehicles are must contain at least 75% regional content (components made in North America). Per Reuters reporting, the Trump admin is seeking to raise the regional requirement to 82%.

These reported plans are subject to change as the US negotiates USMCA terms with Mexico over the next few months.

Overall, Tesla will likely have the easiest time qualifying for any stricter requirements. The automaker’s vehicles contained the highest amount of US/Canadian content in 2025, according to American University research. Ford, GM, and Stellantis all scored lower.

Notably: the underlying government data that many domestic content measurements rely on intentionally combines US and Canadian components, so it’s difficult to know exactly how much of any given vehicle is specifically US-made.

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